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Clin Chest Med. 2006 Mar;27(1):29-40, v.

Physiologic and pathologic abnormalities in severe asthma.

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Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA.


Severe asthma remains poorly understood and frustrating to treat, partly because it is a heterogeneous disease. Recent improvements in the definition of severe asthma have allowed better characterization of the phenotypes of severe asthma and the related physiologic and pathologic abnormalities. Early-onset severe asthma is a more allergy-associated disease than late-onset asthma. Persistent eosinophilia is more commonly seen in patients who have late-onset disease but is associated with a more symptomatic disease in both early- and late-onset disease. Recent studies suggest that response to therapy in severe asthma may depend on the phenotype.

[Indexed for MEDLINE]

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