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Trends Biotechnol. 2006 May;24(5):235-43. Epub 2006 Mar 15.

Mastering the complexity of DNA nanostructures.

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Department of Biochemistry, G. Moruzzi University of Bologna, Via Irnerio 48, Bologna 40126, Italy.


The self-assembly of oligodeoxynucleotides is a versatile and powerful tool for the construction of objects in the nanoscale. The strictly information-driven pairing of DNA fragments can be used to rationally design and build nanostructures with planned topologies and geometries. Taking advantage of the steadily expanding library of well-characterized DNA motifs, several examples of structures with different dimensionalities have appeared in the literature in the past few years, laying the foundations for a promising DNA-mediated, bottom-up approach to nanotechnology. This article focuses on recent developments in this area of research and proposes a classification of DNA nanostructures based on topological considerations in addition to describing strategies for tackling the inherent complexities of such an endeavor.

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