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Am J Gastroenterol. 2006 Mar;101(3):460-3.

Increasing yield also increases false positives and best serves to exclude GERD.

Abstract

Multiple diagnostic tests always improve diagnostic yield. However, with the addition of more true positives come more false positives. Therefore, positive predictive values likely decrease with additional testing. We show this is true even when no gold standard exists to verify the dual testing's sensitivity and specificity.

[Indexed for MEDLINE]

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