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Prostate. 2006 Jun 15;66(9):945-53.

Energy balance alters dunning R3327-H prostate tumor architecture, androgen receptor expression, and nuclear morphometry in rats.

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1
Division of Hematology and Oncology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA.

Abstract

BACKGROUND:

We hypothesize that diet or energy restriction may alter prostate tumor architecture and nuclear morphometry in a manner predictive of indolent biology.

METHODS:

Adult male rats bearing the Dunning R3327-H tumor were provided free-access to the AIN76 diet or 30% diet/energy restriction for 16 weeks. Tumor tissue was harvested and stained for biomarker evaluation by quantitative digital image analysis.

RESULTS:

Compared to controls, tumors from restricted rats showed a contracted stromal compartment with an increased epithelial/glandular area, and a greater number of smaller and more homogeneous glands. In parallel, the nuclei in tumors harvested from diet-restricted rats were smaller in size, showed a lower proportion with androgen receptor (AR) staining, and reduced intensity of AR staining.

CONCLUSIONS:

Our observations support the hypothesis that diet/energy restriction alters prostate tumor architecture, AR expression, and nuclear morphology consistent with a more differentiated and less aggressive phenotype.

PMID:
16541424
DOI:
10.1002/pros.20406
[Indexed for MEDLINE]
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