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Biochim Biophys Acta. 1991 Sep 3;1094(2):243-5.

Phorbol ester induces phosphorylation and down-regulation of connexin 43 in WB cells.

Author information

1
School of Biological Sciences, Flinders University, Adelaide, Australia.

Abstract

Western blot analysis indicated that WB cells contained multiple proteins of molecular mass 42-47 K which reacted with anti-connexin 43 antibody. Incubation of cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) for 5 min caused the inhibition of dye transfer and the appearance of reactive material of 50 K which was abolished by acid phosphatase. Longer term incubation with TPA caused loss of connexin 43 protein.

PMID:
1654122
DOI:
10.1016/0167-4889(91)90016-q
[Indexed for MEDLINE]

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