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Med Sci Sports Exerc. 2006 Mar;38(3):598-604.

Effect of caffeine on leg muscle pain during cycling exercise among females.

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University of Illinois at Urbana-Champaign, Department of Kinesiology and Community Health, Urbana, IL, USA.



This double-blind, within-subjects experiment examined the effects of ingesting two doses of caffeine on perceptions of leg muscle pain during moderate-intensity cycling exercise among females.


Low-caffeine-consuming college-aged females (N = 11) ingested one of two doses of caffeine (5 or 10 mg x kg(-1) body weight) or a placebo and 1 h later completed 30 min of cycling on an ergometer at approximately 60% VO2peak. The conditions were completed in a counterbalanced order. Perceptions of leg muscle pain as well as power output, heart rate, systolic blood pressure, and oxygen consumption (VO2) were recorded during exercise.


Caffeine had a significant effect on leg muscle pain ratings [F (2,20) = 10.63, P = 0.001, n2 = 0.52]. The mean pain intensity scores during exercise after ingesting 10 mg x kg(-1) body weight caffeine, 5 mg x kg(-1) body weight caffeine, and placebo were 1.6 +/- 1.1, 1.3 +/- 0.7, and 2.4 +/- 1.1, respectively.


The results support that caffeine ingestion has a large effect on reducing leg muscle pain during exercise among females, but this effect does not appear to be dose-dependent between 5 and 10 body weight caffeine.

[Indexed for MEDLINE]

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