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J Exp Med. 2006 Mar 20;203(3):505-11. Epub 2006 Mar 13.

Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo.

Author information

1
Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, and Department of Pathology, New York University School of Medicine, New York, NY 10016, USA.

Abstract

Regulatory T (T reg) cells exert powerful down-modulatory effects on immune responses, but it is not known how they act in vivo. Using intravital two-photon laser scanning microscopy we determined that, in the absence of T reg cells, the locomotion of autoantigen-specific T cells inside lymph nodes is decreased, and the contacts between T cells and antigen-loaded dendritic cells (DCs) are of longer duration. Thus, T reg cells can exert an early effect on immune responses by attenuating the establishment of stable contacts during priming of naive T cells by DCs.

PMID:
16533880
PMCID:
PMC2118249
DOI:
10.1084/jem.20050783
[Indexed for MEDLINE]
Free PMC Article

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