Format

Send to

Choose Destination
See comment in PubMed Commons below
Naunyn Schmiedebergs Arch Pharmacol. 2006 Mar;372(6):465-75. Epub 2006 Mar 11.

Drug transporters in pharmacokinetics.

Author information

1
Institute of Pharmacology and Toxicology, Frankfurter Str. 107, 35392, Giessen, Germany. Ernst.petzinger@vetmed.uni-giessen.de

Abstract

This review deals with the drug transporters allowing drugs to enter and leave cells by carrier-mediated pathways. Emphasis is put on liver transporters but systems in gut, kidney, and blood-brain barrier are mentioned as well. Drug-drug interactions on carriers may provoke significant modification in pharmacokinetics as do carrier gene polymorphisms yielding functional carrier protein mutations. An integrated phase concept should reflect the interplay between drug metabolism and drug transport.

PMID:
16532306
DOI:
10.1007/s00210-006-0042-9
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center