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Eur Urol. 2006 Jul;50(1):112-7; discussion 117-8. Epub 2006 Mar 6.

Systemic nitric oxide augmentation leads to a rapid decrease of the bladder outlet resistance in healthy men.

Author information

1
Department of Urology, University Hospital, Zurich, Switzerland. muntener@jhmi.edu

Abstract

OBJECTIVE:

We examined the immediate effect of a systemic nitric oxide augmentation on the bladder outlet resistance in healthy men.

METHODS:

Eleven healthy male volunteers with a mean age of 25.5 yr were included in the study. They were prepared for a standard urodynamic study, and a baseline pressure-flow study was obtained. The subjects were then given 20 mg isosorbide dinitrate sublingually, and after refilling their bladder a second pressure-flow study was done after 20 min. The pressure-flow studies were then compared in regard to the average flow rate, the average detrusor pressure during micturition, and the detrusor pressure at maximum flow rate.

RESULTS:

One of the subjects was unable to void and had to be excluded from the study. In the remaining 10 men, the mean average flow rate increased from 16.7 ml/s before to 20.2 ml/s after the intake of the NO donor (P=0.013). Concomitantly, the average detrusor pressure during micturition decreased from a mean of 57 to 52 cm H2O (P=0.004) and the mean detrusor pressure at maximum flow rate decreased from 60 to 52 cm H2O (P=0.013).

CONCLUSIONS:

Systemic NO augmentation can lower the functional bladder outlet resistance very rapidly in men. Our results support the concept that the NO-cGMP pathway may be a promising target for medical treatment of lower urinary tract symptoms.

PMID:
16530931
DOI:
10.1016/j.eururo.2006.02.036
[Indexed for MEDLINE]

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