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Dent Clin North Am. 2006 Apr;50(2):157-73, vii.

Salivary gland gene therapy.

Author information

1
Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-1190, USA.

Abstract

Salivary glands have proven to be unusual but valuable target sites for multiple clinical gene transfer applications. Access to salivary glands for gene transfer is easy. Multiple studies in animal models have yielded proofs of concept for novel treatments for damaged salivary glands following therapeutic irraditation, in Sjögren's syndrome, and for gene therapeutics systemically by way of the blood-stream and locally in the oral cavity and upper gastrointestinal tract.

PMID:
16530055
DOI:
10.1016/j.cden.2005.11.002
[Indexed for MEDLINE]

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