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Cell. 2006 Mar 10;124(5):888-90.

TOPping up ATR activity.

Author information

1
Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark. jb@cancer.dk

Abstract

The nuclear protein kinase ATR is a key regulator of genome integrity that functions at checkpoints for damaged or incompletely replicated DNA. In this issue of Cell, Kumagai et al. (2006) shed light on the molecular mechanism that controls ATR. They report that a physical interaction between ATR and a distinct domain of TopBP1 greatly enhances ATR kinase activity.

PMID:
16530035
DOI:
10.1016/j.cell.2006.02.029
[Indexed for MEDLINE]
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