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Cell. 2006 Mar 10;124(5):886-8.

A long-distance relationship between RNAi and Polycomb.

Author information

1
Department of Biology, Johns Hopkins University, Baltimore, Maryland, 21218, USA.

Abstract

RNA interference (RNAi) pathways can result in sequence-specific transcriptional gene silencing on the level of chromatin. In this issue of Cell, Grimaud et al. (2006) reveal that the RNAi machinery is required for long-distance physical interactions between chromosomes mediated by the Polycomb repressive complex. These results suggest that the RNAi machinery may regulate higher-order nuclear organization.

PMID:
16530034
DOI:
10.1016/j.cell.2006.02.026
[Indexed for MEDLINE]
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