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Cell. 2006 Mar 10;124(5):883-5.

The Notch transcription activation complex makes its move.

Author information

1
T.C. Jenkins Department of Biophysics, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA.

Abstract

Two papers in this issue of Cell, (Nam et al., 2006; Wilson and Kovall, 2006) report the crystal structure of the Notch transcriptional activation complex. These structures show that the ANK domain of Notch is an integral part of the transcription complex and supports MAM binding, whereas the RAM domain may trigger allosteric changes in the structure needed for the derepression of transcription.

PMID:
16530033
DOI:
10.1016/j.cell.2006.02.028
[Indexed for MEDLINE]
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