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Trends Immunol. 2006 Apr;27(4):188-94. Epub 2006 Mar 10.

A gut feeling for joint inflammation - using coeliac disease to understand rheumatoid arthritis.

Author information

1
Institute of Immunology and Department of Rheumatology, Rikshospitalet University Hospital, University of Oslo, N-0027 Oslo, Norway. oyvind.molberg@medisin.uio.no

Erratum in

  • Trends Immunol. 2006 Jun;27(6):254.

Abstract

Major advances have been made in the molecular understanding of coeliac disease, initiated by the identification of intestinal gluten-reactive T cells. It is now clear that this common intestinal disorder, which is precipitated by the ingestion of wheat gluten, is mediated by DQ2-restricted T cells specific for gluten peptides modified by transglutaminase 2, the same enzyme that is targeted by disease-specific autoantibodies. Interestingly, many of the important features identified in coeliac disease, including HLA association, target organ T-cell infiltration, disease-specific autoantibodies and the distinct targeting of in vivo modified antigens, are also present in rheumatoid arthritis. The experiences from coeliac disease should therefore help identify disease-relevant T-cell epitopes in rheumatoid arthritis.

PMID:
16530013
DOI:
10.1016/j.it.2006.02.006
[Indexed for MEDLINE]

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