Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2006 May 15;16(10):2791-5. Epub 2006 Mar 10.

5-Piperazinyl pyridine carboxamide bradykinin B1 antagonists.

Author information

1
Department of Medicinal Chemistry, Merck Research Laboratories, Sumneytown Pike, PO Box 4, West Point, PA 19486, USA. scott_d_kuduk@merck.com

Abstract

A series of 2,3-diaminopyridine bradykinin B(1) antagonists was modified to mitigate the potential for bioactivation. Removal of the 3-amino group and incorporation of basic 5-piperazinyl carboxamides at the pyridine 5-position provided compounds with high affinity for the human B(1) receptor.

PMID:
16529929
DOI:
10.1016/j.bmcl.2006.01.112
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center