Send to

Choose Destination
Curr Opin Cell Biol. 1991 Apr;3(2):213-7.

Cyclic AMP second messenger systems.

Author information

Department of Pharmacology, University of Washington, Seattle 98195.


Cells carefully regulate the generation and destruction of cAMP using diverse families of adenylate cyclases and phosphodiesterases. Genes for several cyclases have now been cloned, giving structural information about the enzymes and providing access to the remaining members of this family. A much larger family of phosphodiesterases has been uncovered and the regulatory properties of both the cyclases and phosphodiesterases provide diverse mechanisms to modulate intracellular cAMP. Most of the actions of cAMP are mediated through phosphorylation of substrates of the cAMP-dependent protein kinases. Recent progress has helped define the pathway between cAMP and the activation of gene transcription.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center