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J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Apr 3;833(2):179-85. Epub 2006 Mar 9.

A rapid LC-MS method for determination of plasma anion profiles of acidotic patients.

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  • 1Renal Research Laboratory, Department Medicine, 4th Floor, North Wing, St. Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, UK.


In metabolic acidosis, the concentrations of anions associated with intermediary metabolism are increased and can make a significant contribution to the observed acidosis. Here we describe a method for the rapid determination of the plasma ultrafiltrate profile of these anions using liquid chromatography coupled to electrospray ionisation mass spectrometry (LC/ESI-MS). The ultrafiltrate from patients with acidosis resulting from various causes were examined and the results compared to control values. Using the LC/ESI-MS method described, a unique plasma ultrafiltrate anion profile was obtained for each of the groups studied that provides rapid diagnosis of the type of underlying acidosis.

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