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FEBS Lett. 1991 Aug 5;287(1-2):39-41.

Hemorphins derived from hemoglobin have an inhibitory action on angiotensin converting enzyme activity.

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  • 1Uppsala University, Department of Pharmacology, Sweden.


The hemorphins are opioid active peptides, which are enzymatically released from the beta-chain of hemoglobin. In this paper we report an inhibitory effect of these peptides on angiotensin converting enzyme (ACE) activity, known to be involved in blood pressure regulation. The hemorphins were found to be quite stable in tissue extracts containing ACE, and their importance as naturally occurring ACE inhibitors is discussed.

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