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J Neurol Sci. 2006 May 15;244(1-2):117-22. Epub 2006 Mar 9.

Neurological manifestations of dengue virus infection.

Author information

1
Department of Neurology, Sanjay Gandhi PGIMS, Lucknow 226014, India. ukmisra@sgpgi.ac.in

Abstract

AIM:

Paucity of studies on neurological manifestations in dengue virus infection prompted this study. We aim to correlate clinical, radiological and neurophysiological changes in dengue patients with neurological manifestations.

METHOD:

Consecutive IgM seropositive dengue patients admitted in neurology ward during 2003-2005 have been prospectively evaluated. They were subjected to detailed clinical evaluation, blood counts, coagulation profile, serum chemistry including creatine kinase (CK), cerebrospinal fluid (CSF), cranial CT and/or MRI, electroencephalogram (EEG), nerve conduction and needle electromyography (EMG).

RESULTS:

There were 17 patients, aged 5 to 56 years; 11 presented with encephalopathy and 6 with acute motor weakness. In the patients with encephalopathy, seizures were present in 3, myoclonus in 1, CSF pleocytosis and EEG slowing in 8 each and globus pallidus and thoracic spinal cord involvement on MRI in 1 patient each. In the pure motor weakness group, CK was elevated in 5 and EMG and muscle biopsy were consistent with myositis in 1 patient each. The patients with pure motor weakness improved completely but in the encephalopathy group 3 died, 2 had partial, 1 poor and 5 complete recovery by 1 month.

CONCLUSION:

Dengue patients presenting with encephalopathy had more severe illness and worse outcome compared to acute pure motor weakness.

PMID:
16524594
DOI:
10.1016/j.jns.2006.01.011
[Indexed for MEDLINE]

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