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Pigment Cell Res. 2006 Apr;19(2):112-24.

NF-kappaB activation in melanoma.

Author information

1
Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.

Abstract

Metastatic melanoma is an aggressive skin cancer that is notoriously resistant to current cancer therapies. In human melanoma, nuclear factor-kappa B (NF-kappaB) is upregulated, leading to the deregulation of gene transcription. In this review, we discuss (i) the relationship between gene alteration in melanoma and upregulation of NF-kappaB, (ii) mechanisms by which activated NF-kappaB switch from pro-apoptotic to anti-apoptotic functions in melanoma and (iii) autocrine mechanisms that promote constitutive activation of NF-kappaB in metastatic melanoma.

PMID:
16524427
PMCID:
PMC2668252
DOI:
10.1111/j.1600-0749.2006.00304.x
[Indexed for MEDLINE]
Free PMC Article

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