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BMC Musculoskelet Disord. 2006 Mar 7;7:23.

Transcriptome-scale similarities between mouse and human skeletal muscles with normal and myopathic phenotypes.

Author information

1
Children's Hospital Informatics Program, Harvard-MIT Division of Health Sciences and Technology, Cambridge, Massachusetts, USA. alvin_kho@hms.harvard.edu

Abstract

BACKGROUND:

Mouse and human skeletal muscle transcriptome profiles vary by muscle type, raising the question of which mouse muscle groups have the greatest molecular similarities to human skeletal muscle.

METHODS:

Orthologous (whole, sub-) transcriptome profiles were compared among four mouse-human transcriptome datasets: (M) six muscle groups obtained from three mouse strains (wildtype, mdx, mdx5cv); (H1) biopsied human quadriceps from controls and Duchenne muscular dystrophy patients; (H2) four different control human muscle types obtained at autopsy; and (H3) 12 different control human tissues (ten non-muscle).

RESULTS:

Of the six mouse muscles examined, mouse soleus bore the greatest molecular similarities to human skeletal muscles, independent of the latters' anatomic location/muscle type, disease state, age and sampling method (autopsy versus biopsy). Significant similarity to any one mouse muscle group was not observed for non-muscle human tissues (dataset H3), indicating this finding to be muscle specific.

CONCLUSION:

This observation may be partly explained by the higher type I fiber content of soleus relative to the other mouse muscles sampled.

PMID:
16522209
PMCID:
PMC1525166
DOI:
10.1186/1471-2474-7-23
[Indexed for MEDLINE]
Free PMC Article
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