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Protein Pept Lett. 2005 Oct;12(7):677-86.

Predicted and measured disorder in peripherin/rds, a retinal tetraspanin.

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1
Eye Research Institute, Oakland University, Rochester, MI 48309, USA.

Abstract

Vertebrate photoreceptor outer segment (OS) morphogenesis requires peripherin/rds (P/rds). We have characterized this protein's C-terminus and present evidence that suggests it is intrinsically disordered. We propose that structural flexibility may underlie the multifunctionality proposed for this domain previously. The extremely short C-termini present in other tetraspanin family members suggest that intrinsic disorder may also play a role for those proteins.

PMID:
16522184
PMCID:
PMC1398073
[Indexed for MEDLINE]
Free PMC Article
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