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J Cell Biol. 2006 Mar 13;172(6):803-8. Epub 2006 Mar 6.

RNA granules.

Author information

1
Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA.

Abstract

Cytoplasmic RNA granules in germ cells (polar and germinal granules), somatic cells (stress granules and processing bodies), and neurons (neuronal granules) have emerged as important players in the posttranscriptional regulation of gene expression. RNA granules contain various ribosomal subunits, translation factors, decay enzymes, helicases, scaffold proteins, and RNA-binding proteins, and they control the localization, stability, and translation of their RNA cargo. We review the relationship between different classes of these granules and discuss how spatial organization regulates messenger RNA translation/decay.

PMID:
16520386
PMCID:
PMC2063724
DOI:
10.1083/jcb.200512082
[Indexed for MEDLINE]
Free PMC Article

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