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J Cell Biol. 2006 Mar 13;172(6):937-48. Epub 2006 Mar 6.

Neuron to glia signaling triggers myelin membrane exocytosis from endosomal storage sites.

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  • 1Centre for Biochemistry and Molecular Cell Biology, University of Göttingen, 37073 Göttingen, Germany.

Abstract

During vertebrate brain development, axons are enwrapped by myelin, an insulating membrane produced by oligodendrocytes. Neuron-derived signaling molecules are temporally and spatially required to coordinate oligodendrocyte differentiation. In this study, we show that neurons regulate myelin membrane trafficking in oligodendrocytes. In the absence of neurons, the major myelin membrane protein, the proteolipid protein (PLP), is internalized and stored in late endosomes/lysosomes (LEs/Ls) by a cholesterol-dependent and clathrin-independent endocytosis pathway that requires actin and the RhoA guanosine triphosphatase. Upon maturation, the rate of endocytosis is reduced, and a cAMP-dependent neuronal signal triggers the transport of PLP from LEs/Ls to the plasma membrane. These findings reveal a fundamental and novel role of LEs/Ls in oligodendrocytes: to store and release PLP in a regulated fashion. The release of myelin membrane from LEs/Ls by neuronal signals may represent a mechanism to control myelin membrane growth.

PMID:
16520383
PMCID:
PMC2063736
DOI:
10.1083/jcb.200509022
[PubMed - indexed for MEDLINE]
Free PMC Article
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