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J HIV Ther. 2005 Dec;10(4):68-71.

CCR5 antagonists: a new tool in fighting HIV.

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Department of Infectious Diseases, Medical Policlinic, Ludwig Maximilian University, Munich, Germany.


Chemokine receptors are essential for cell entry by HIV. The two chemokine receptors most relevant to this process are CC chemokine receptor 5 (CCR5) and CXC chemokine receptor 4 (CXCR4) since a delayed onset of disease can be achieved by inhibition of either receptor. Therefore, chemokine receptor antagonists, in particular inhibitors of CCR5, represent a promising new class of anti-HIV agents. In this review, we summarise current drug candidates, give an insight into how they interact with CCR5, and discuss requirements and restrictions for these compounds.

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