Use of enzyme-linked immunospot assay with Mycobacterium tuberculosis-specific peptides for diagnosis of recent infection with M. tuberculosis after accidental laboratory exposure

J Clin Microbiol. 2006 Mar;44(3):1197-201. doi: 10.1128/JCM.44.3.1197-1201.2006.

Abstract

This report of an accidental exposure to Mycobacterium tuberculosis in a microbiological laboratory illustrates the value of gamma interferon enzyme-linked immunospot assay using peptides of ESAT-6, CFP-10, TB37.6, and TB7.7 for the diagnosis of latent infection. In particular, positive responses to peptides 2 to 6 of TB37.6 were observed exclusively in recently infected persons.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Accidents, Occupational
  • Bacterial Proteins / isolation & purification
  • Enzyme-Linked Immunosorbent Assay / methods
  • Humans
  • Laboratories
  • Male
  • Mycobacterium tuberculosis / isolation & purification*
  • Netherlands
  • Occupational Diseases / diagnosis
  • Occupational Diseases / etiology
  • Occupational Diseases / microbiology
  • Occupational Exposure
  • Peptides / isolation & purification
  • Tuberculosis, Pulmonary / diagnosis*
  • Tuberculosis, Pulmonary / etiology*
  • Tuberculosis, Pulmonary / microbiology

Substances

  • Bacterial Proteins
  • Peptides