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Dev Cell. 2006 Mar;10(3):280-1.

Bruno: a double turn-off for Oskar.

Author information

1
Wellcome Trust Centre for Cell Biology, Michael Swann Building, School of Biological Sciences, The University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, United Kingdom.

Abstract

In Drosophila, the posterior localization of oskar mRNA and its translational regulation are essential for axis specification and germline formation. Recently in Cell, demonstrated that Bruno inhibits cap-dependent translation of oskar mRNA and uncovered a novel Bruno-dependent assembly of oskar mRNA into multimeric RNP particles, which are inaccessible to the translational machinery. This work provides a novel link between mRNA localization, particle formation, and translational regulation.

PMID:
16516832
DOI:
10.1016/j.devcel.2006.02.001
[Indexed for MEDLINE]
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