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Bioorg Med Chem Lett. 2006 May 15;16(10):2608-12. Epub 2006 Mar 3.

Nitrogen-bridged substituted 8-arylquinolines as potent PDE IV inhibitors.

Author information

1
Merck Frosst Center for Therapeutic Research, PO Box 1005, Pointe Claire-Dorval, Que., Canada H9R 4P8. patrick_lacombe@merck.com

Abstract

Potent inhibitors of the human PDE IV enzyme are described. Substituted 8-arylquinoline analogs bearing nitrogen-linked side chain were identified as potent inhibitors based on the SAR described herein. The pharmacokinetic profile of the best analog and the in vivo efficacy in an ovalbumin-induced bronchoconstriction assay in conscious guinea pigs are reported.

PMID:
16516471
DOI:
10.1016/j.bmcl.2006.02.043
[Indexed for MEDLINE]

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