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J Biotechnol. 2006 Jun 25;124(1):196-205. Epub 2006 Mar 3.

The use of microorganisms in L-ascorbic acid production.

Author information

  • 1Forschungszentrum Jülich GmbH, Institut für Biotechnologie 1, Jülich, Germany.

Abstract

L-Ascorbic acid has been industrially produced for around 70 years. Over the past two decades, several innovative bioconversion systems have been proposed in order to simplify the long time market-dominating Reichstein method, a largely chemical synthesis by which still a considerable part of L-ascorbic acid is produced. Here, we describe the current state of biotechnological alternatives using bacteria, yeasts, and microalgae. We also discuss the potential for direct production of l-ascorbic acid exploiting novel bacterial pathways. The advantages of these novel approaches competing with current chemical and biotechnological processes are outlined.

PMID:
16516325
DOI:
10.1016/j.jbiotec.2006.01.010
[PubMed - indexed for MEDLINE]
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