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Mini Rev Med Chem. 2006 Mar;6(3):331-7.

Effects of the natural isoflavonoid genistein on growth, signaling pathways and gene expression of matrix macromolecules by breast cancer cells.

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Laboratory of Biochemistry, Department of Chemistry, University of Patras, 261 10 Patras, Greece.


Genistein is a well known protein tyrosine kinase inhibitor. It is structurally similar to 17beta-estradiol and exerts antiestrogenic effects. It also affects the signal transduction components Akt, FAK, ErbB-2 and Bcl-2. Key enzymes implicated in cancer invasion are also affected by genistein. A critical evaluation of the effects of genistein on breast cancer growth, signaling and gene expression is presented in this review.

[Indexed for MEDLINE]

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