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Cytokine Growth Factor Rev. 2006 Jun;17(3):189-201. Epub 2006 Mar 2.

High-mobility group box 1 (HMGB1) protein: friend and foe.

Author information

1
Center of Immunology and Inflammation, North Shore University Hospital, 350 Community Drive, Manhasset, NY 11030, USA. Contact@LuisUlloa.com

Abstract

HMGB1 was originally identified as a DNA-binding protein that functions as a structural co-factor critical for proper transcriptional regulation in somatic cells. Recent studies indicate that HMGB1 can be "passively released" into the extracellular milieu by necrotic and damaged somatic cells. Extracellular HMGB1 represents an optimal "necrotic marker" selected by the innate immune system to recognize tissue damage and initiate reparative responses. HMGB1 in the extracellular milieu promotes maturation of myeloid and plasmacytoid dendritic cells, and induces myocardial regeneration after infarction. However, extracellular HMGB1 also acts as a potent pro-inflammatory cytokine that contributes to the pathogenesis of diverse inflammatory and infectious disorders. A growing number of studies indicate that HMGB1 is a successful therapeutic target in experimental models of ischemia/reperfusion, acute respiratory distress syndrome, rheumatoid arthritis, sepsis, and cancer. From a clinical perspective, HMGB1 represents a current challenge that can be exploited orchestrate reparative responses while preventing its pathological potential. This article focus on the immuno-regulatory role of HMGB1 and its contribution to infectious and inflammatory disorders.

PMID:
16513409
DOI:
10.1016/j.cytogfr.2006.01.003
[Indexed for MEDLINE]

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