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Trends Pharmacol Sci. 2006 Apr;27(4):186-9. Epub 2006 Mar 2.

Clock genes: influencing and being influenced by psychoactive drugs.

Author information

1
Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, Chicago, IL 60612, USA. Hmanev@psych.uic.edu

Abstract

Although clock genes are the hallmark of circadian rhythms, they are also currently considered as transcription factors that have a prominent role in the pharmacology of the CNS. The expression of these transcription factors in the mammalian brain is not only intrinsically rhythmic but is also modulated by external inputs and hormones. An altered expression of clock genes, as evidenced in transgenic mice, has a profound influence on the behavioral effects of psychoactive drugs. Focusing on clock genes expressed in the brain might lead to the discovery of novel drug-target pathways.

PMID:
16513182
DOI:
10.1016/j.tips.2006.02.003
[Indexed for MEDLINE]

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