Format

Send to

Choose Destination
See comment in PubMed Commons below
J Cogn Neurosci. 2006 Mar;18(3):444-55.

Executive "brake failure" following deactivation of human frontal lobe.

Author information

1
University of Melbourne, Melbourne, Australia. chris.chambers@ucl.ac.uk

Abstract

In the course of daily living, humans frequently encounter situations in which a motor activity, once initiated, becomes unnecessary or inappropriate. Under such circumstances, the ability to inhibit motor responses can be of vital importance. Although the nature of response inhibition has been studied in psychology for several decades, its neural basis remains unclear. Using transcranial magnetic stimulation, we found that temporary deactivation of the pars opercularis in the right inferior frontal gyrus selectively impairs the ability to stop an initiated action. Critically, deactivation of the same region did not affect the ability to execute responses, nor did it influence physiological arousal. These findings confirm and extend recent reports that the inferior frontal gyrus is vital for mediating response inhibition.

PMID:
16513008
DOI:
10.1162/089892906775990606
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon
    Loading ...
    Support Center