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Methods Mol Med. 2006;122:427-34.

Hypobaric hypoxia as a tool to study pregnancy-dependent responses at the maternal-fetal interface.

Author information

1
Institute of Maternal-Fetal Biology, Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, USA.

Abstract

Establishment of proper oxygen and nutrient supply to the fetus is essential for a successful pregnancy. The maternal-fetal interface is the site of vascular modifications, providing a conduit for the delivery of essential nutrients to the developing fetus. Pregnancy-dependent adaptive vascular responses within the uteroplacental compartment can be exaggerated by exposure to a physiological stressor such as hypoxia. A simple procedure for exposing pregnant rats and mice to hypobaric hypoxia is presented.

PMID:
16511999
[Indexed for MEDLINE]

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