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Clin Infect Dis. 2006 Apr 1;42(7):996-1002. Epub 2006 Feb 22.

Enterobacter sakazakii: an emerging pathogen in powdered infant formula.

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Centre for Food Safety, School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Ireland.


Enterobacter sakazakii represents a significant risk to the health of neonates. This bacterium is an emerging opportunistic pathogen that is associated with rare but life-threatening cases of meningitis, necrotizing enterocolitis, and sepsis in premature and full-term infants. Infants aged <28 days are considered to be most at risk. Feeding with powdered infant formula (PIF) has been epidemiologically implicated in several clinical cases. Infants should be exclusively breast-fed for the first 6 months of life, and those who are not should be provided with a suitable breast-milk substitute. PIF is not a sterile product; to reduce the risk of infection, the reconstitution of powdered formula should be undertaken by caregivers using good hygienic measures and in accordance with the product manufacturer's food safety guidelines.

[Indexed for MEDLINE]

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