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Neurology. 2006 Mar 28;66(6):919-21. Epub 2006 Mar 1.

Valproic acid adjunctive therapy for HIV-associated cognitive impairment: a first report.

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  • 1Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA.


In vitro and animal model data demonstrate that valproic acid (VPA) can ameliorate HIV-associated neurotoxicity. The authors conducted a pilot 10-week placebo-controlled study of VPA 250 mg twice daily in 22 HIV-infected individuals with (n = 16) and without (n = 6) cognitive impairment. VPA was safe and well tolerated, with trends toward improved neuropsychological performance and brain metabolism in the impaired subjects.

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