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Eur J Pharmacol. 2006 Mar 8;533(1-3):40-56. Epub 2006 Feb 28.

Treatment of asthma with antileukotrienes: first line or last resort therapy?

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1
Experimental Asthma and Allergy Research, The National Institute of Environmental Medicine, Karolinska Institute, SE-171 77 Stockholm, Sweden. se.dahlen@imm.ki.se

Abstract

Twenty five years after the structure elucidation of slow reacting substance of anaphylaxis, antileukotrienes are established as a new therapeutic modality in asthma. The chapter reviews the biochemistry and pharmacology of leukotrienes and antileukotrienes with particular focus on the different usage of antileukotrienes for treatment of asthma and rhinitis in Europe and the US. Further research needs and new areas for leukotriene involvement in respiratory diseases are also discussed.

PMID:
16510137
DOI:
10.1016/j.ejphar.2005.12.070
[Indexed for MEDLINE]
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