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Semin Respir Crit Care Med. 2006 Feb;27(1):29-33.

Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia and severe sepsis.

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Service de Réanimation Médicale, Hôpital Central, Nancy Cedex, France.


The triggering receptor expressed on myeloid cells (TREM)-1 is a recently identified molecule involved in the inflammatory response. It belongs to the immunoglobulin superfamily and is expressed on the surface of neutrophils, mature monocytes, and macrophages. The engagement of TREM-1 synergizes with the Toll-like receptors signaling pathway in amplifying the inflammatory response mediated by several microbial components. The expression of the membrane-bound TREM-1 is strongly upregulated on monocytes during sepsis. Besides its membranous form, a soluble counterpart of TREM-1 exists that is specifically released during several infectious processes. The measurement of that soluble form in biological fluids may be useful as a diagnostic tool, especially during severe sepsis and pneumonia. Moreover, the evolutionary pattern of TREM-1 may be interesting during the follow-up of septic patients.

[Indexed for MEDLINE]

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