Send to

Choose Destination
FEBS Lett. 1991 Jul 29;286(1-2):152-4.

Paraoxonase prevents accumulation of lipoperoxides in low-density lipoprotein.

Author information

University Department of Medicine, Manchester Royal Infirmary, UK.

Erratum in

  • FEBS Lett 1991 Nov 4;292(1-2):307.


Oxidative modification of low-density lipoprotein (LDL) enhances its uptake by macrophages in tissue culture and in vivo may underly the formation of arterial fatty streaks, the progenitors of atheroma. We investigated the possible protection which high-density lipoprotein (HDL) affords against LDL oxidation. The formation of lipoperoxides and thiobarbituric acid reactive substances when LDL was incubated with copper ions was significantly decreased by HDL. The enzyme, paraoxonase (E.C., purified from human HDL, had a similar effect and thus may be the component of HDL responsible for decreasing the accumulation of lipid peroxidation products.

[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center