Rookie snail protein LAPS veteran C/EBP: net transcriptional proceeds for long-term facilitation

Kristin L Eckel-Mahan; Daniel R Storm

doi:10.1016/j.neuron.2006.02.009

Rookie snail protein LAPS veteran C/EBP: net transcriptional proceeds for long-term facilitation

Neuron. 2006 Mar 2;49(5):645-6. doi: 10.1016/j.neuron.2006.02.009.

Authors

Kristin L Eckel-Mahan¹, Daniel R Storm

Affiliation

¹ Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA.

PMID: 16504938
DOI: 10.1016/j.neuron.2006.02.009

Abstract

Long-term changes in synaptic plasticity require new protein synthesis. This preview discusses data from Kim et al. (this issues of Neuron) that demonstrate the requirement of a novel, nucleolar protein, LLP (LAPS18-like protein), for the formation of long-term facilitation in Aplysia. LLP binds to and transcriptionally activates C/EBP, thereby promoting the formation of long-term facilitation and behavioral sensitization.

Publication types

Comment

MeSH terms

Animals
Aplysia / cytology
Aplysia / physiology*
Avoidance Learning / physiology
CCAAT-Enhancer-Binding Proteins / physiology*
Long-Term Potentiation / physiology*
Models, Biological
Transcription Factors / physiology*
Transcriptional Activation / physiology

Substances

CCAAT-Enhancer-Binding Proteins
Transcription Factors