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Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Mar;101(3):309-16. Epub 2005 Sep 26.

Acceleration of de novo bone formation following application of autogenous bone to particulated anorganic bovine material in vivo.

Author information

1
Department of Oral and Maxillofacial Surgery/Plastic Surgery, University of Jena, Jena, Germany. Michael.Thorwarth@med.uni-jena.de

Abstract

OBJECTIVE:

This prospective animal study examined the de novo bone formation following application of deproteinized bovine bone matrix (DBBM) with or without autogenous bone (AB) to osseous defects.

STUDY DESIGN:

Defects of defined size were created in the frontal skull of domestic pigs and filled with DBBM alone (group A) and DBBM+25%AB (group B). De novo bone formation was analyzed qualitatively and quantitatively at 9 different times (0.5, 1, 2, 3, 4, 6, 8, 12, 26 weeks) by means of light microscopy, microradiography, and statistical analysis.

RESULTS:

Histological analysis indicated sufficient osseointegration of DBBM in both groups. Microradiography demonstrated a significant increase of bone formation in group B after 6 weeks (P = .0159) and 8 weeks (P = .0317).

CONCLUSION:

The addition of 25%AB to DBBM results in accelerated de novo bone formation in osseous defects. This effect is likely caused by osteoinductive properties of cellular elements transplanted with the autogenous bone.

PMID:
16504863
DOI:
10.1016/j.tripleo.2005.04.024
[Indexed for MEDLINE]
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