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Bioorg Med Chem Lett. 2006 May 15;16(10):2662-5. Epub 2006 Feb 28.

Synthesis of a potent 5'-methylthioadenosine/S-adenosylhomocysteine (MTAN) inhibitor.

Author information

1
BioCryst Pharmaceuticals Inc., 2190 Parkway Lake Drive, Birmingham, AL 35244, USA.

Abstract

MTAN has been known to occur in a variety of bacterial cell types. Due to the evolution of bacterial strains which are resistant to some of the most powerful antibiotics there has been a renewed interest in the development of novel anti-microbial agents. Presented herein is a synthesis of a potent MTAN inhibitor, namely 2-amino-4-[5-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-3,4-dihydroxypyrrolidin-2-ylmethylsulfanyl]-butyric acid (1).

PMID:
16504506
DOI:
10.1016/j.bmcl.2006.02.029
[Indexed for MEDLINE]

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