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Curr Opin Genet Dev. 2006 Apr;16(2):177-83. Epub 2006 Feb 28.

A question of timing: emerging links between transcription and replication.

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Friedrich-Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland.


The coordination of transcription and timing of DNA replication during the S phase of the cell cycle has recently been studied chromosome-wide in high resolution. This revealed that in the complex genome of higher eukaryotes actively transcribed genes are more likely to replicate early in S phase. Dynamic changes in chromatin structure and nuclear organization appear to provide the underlying mechanism to link transcription and replication. A possible evolutionary benefit for this connection might result from differential replication fidelity during S phase, and comparisons of the human and chimpanzee genomes are compatible with this hypothesis.

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