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Breast Cancer Res Treat. 2006 Sep;99(1):19-21. Epub 2006 Feb 24.

Prediction of breast cancer using volatile biomarkers in the breath.

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1
Menssana Research Inc., 1 Horizon Road, Suite 1415, Fort Lee, NJ 07024, USA. mphillips@menssanaresearch.com

Abstract

We evaluated a breath test for volatile organic compounds (VOCs) as a predictor of breast cancer. Breath VOCs were assayed in 51 asymptomatic women with abnormal mammograms and biopsy-proven breast cancer, and 42 age-matched healthy women. A fuzzy logic model predicted breast cancer with accuracy superior to previously reported findings. Following random assignment to a training set (64) or a prediction set (29), a model was constructed in the training set employing five breath VOCs that predicted breast cancer in the prediction set with 93.8% sensitivity and 84.6% specificity. The same model predicted no breast cancer in 16/50 (32.0%) women with abnormal mammograms and no cancer on biopsy. A two-minute breath test could potentially provide a safe, accurate and painless screening test for breast cancer, but prospective validation studies are required.

PMID:
16502014
DOI:
10.1007/s10549-006-9176-1
[Indexed for MEDLINE]
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