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Nervenarzt. 2006 Sep;77(9):1096-100, 1102-4.

[Cycloid psychoses as atypical manic-depressive disorders. Results of a family study].

[Article in German]

Author information

1
Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universität Würzburg, Füchsleinstrasse 15, 97080, Würzburg, Germany. burkhard.jabs@mail.uni-wuerzburg.de

Abstract

BACKGROUND:

Whereas a growing body of evidence suggests that cycloid psychoses have to be separated from schizophrenic psychoses, their relations to bipolar affective disorder are less clear.

PATIENTS AND METHODS:

In a controlled family study, we recruited 46 patients with cycloid psychosis (CP), 33 with manic-depressive illness (MDI), and 27 controls. Three hundred fifty-six of 389 living first-degree relatives were personally examined by experienced psychiatrists blinded to the diagnosis of the index proband.

RESULTS:

The relatives of CP patients showed significantly lower morbidity risk of functional psychoses than relatives of patients with MDI in Kaplan-Meier life table calculation. The morbidity risk for functional psychoses in relatives of patients with CP did not differ significantly from that in relatives of controls.

CONCLUSION:

These results suggest that CP are etiologically different from bipolar affective psychoses and cannot be integrated into the spectrum of bipolar affective disorders. The findings provide further evidence for a nosological independence of CP.

PMID:
16502008
DOI:
10.1007/s00115-006-2077-z
[Indexed for MEDLINE]

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