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J Biol Chem. 2006 Apr 28;281(17):11910-6. Epub 2006 Feb 24.

Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation.

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1
Department of Neurobiology and Behavior, Center for Neurobiology of Learning and Memory, University of California, Irvine, California 92697-3800, USA.

Abstract

Wnts are important for various developmental and oncogenic processes. Here we show that Wnt signaling functions at synapses in hippocampal neurons. Tetanic stimulations induce N-methyl-d-aspartate receptor-dependent synaptic Wnt3a release, nuclear beta-catenin accumulations, and the activation of Wnt target genes. Suppression of Wnt signaling impairs long term potentiation. Conversely, activation of Wnt signaling facilitates long term potentiation. These findings suggest that Wnt signaling plays a critical role in regulating synaptic plasticity.

PMID:
16501258
DOI:
10.1074/jbc.M511920200
[Indexed for MEDLINE]
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