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Nat Rev Cancer. 2006 Mar;6(3):217-26.

ASPP [corrected] and cancer.

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Ludwig Institute for Cancer Research, Courtauld Building, 91 Riding House Street, London W1W 7BS, UK.

Erratum in

  • Nat Rev Cancer. 2006 May;6(5):414.


One of the most frequently mutated genes in human cancers, tumour suppressor p53 (TP53), can induce cell-cycle arrest and apoptosis. The apoptotic function of p53 is tightly linked to its tumour-suppression function and the efficacy of many cancer therapies depends on this. The identification of a new family of proteins, known as ASPPs (ankyrin-repeat-, SH3-domain- and proline-rich-region-containing proteins), has led to the discovery of a novel mechanism that selectively regulates the apoptotic function, but not the cell-cycle-arrest function, of p53, and gives an insight into how p53 responds to different stress signals. ASPPs might be new molecular targets for cancer therapy.

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