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Prostate. 2006 Jun 15;66(9):895-902.

Loss of PTEN is associated with progression to androgen independence.

Author information

1
The Prostate Centre, Vancouver General Hospital, Vancouver, British Columbia, Canada.

Abstract

BACKGROUND:

Progression to a lethal androgen-independent (AI) stage of advanced prostate cancer is a critical clinical obstacle limiting patient survival. PTEN inactivation is frequently observed in advanced prostate cancer and correlates with a poor prognosis. However, the functional significance of PTEN inactivation in AI progression has not been demonstrated.

METHODS:

PTEN expression was examined in benign, hormone naïve and AI human prostate cancer specimens, and in recurrent AI Shionogi tumors. The effect of antisense oligonucleotide (ASO)-mediated PTEN downregulation in AI progression of the Shionogi tumor model was determined.

RESULTS:

Significantly reduced PTEN expression was observed in AI versus benign and hormone naïve prostate tumors. Seven of 14 AI Shionogi tumors exhibited marked downregulation or complete loss of PTEN. ASO-mediated PTEN inhibition reduced androgen-withdrawal induced regression of Shionogi tumors and accelerated AI progression.

CONCLUSIONS:

These data suggest that PTEN inactivation may play a role in progression to androgen independence.

PMID:
16496415
DOI:
10.1002/pros.20411
[Indexed for MEDLINE]

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