Format

Send to

Choose Destination
Nat Rev Mol Cell Biol. 2006 Mar;7(3):188-97.

Structural systems biology: modelling protein interactions.

Author information

1
Instituci├│ Catalana de Recerca i Estudis Avan├žats, Barcelona, Spain.

Abstract

Much of systems biology aims to predict the behaviour of biological systems on the basis of the set of molecules involved. Understanding the interactions between these molecules is therefore crucial to such efforts. Although many thousands of interactions are known, precise molecular details are available for only a tiny fraction of them. The difficulties that are involved in experimentally determining atomic structures for interacting proteins make predictive methods essential for progress. Structural details can ultimately turn abstract system representations into models that more accurately reflect biological reality.

PMID:
16496021
DOI:
10.1038/nrm1859
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center