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Nat Rev Mol Cell Biol. 2006 Mar;7(3):177-87.

Building mammalian signalling pathways with RNAi screens.

Author information

  • 1Whitehead Institute, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA.

Abstract

Technological advances in mammalian systems are providing new tools to identify the molecular components of signalling pathways. Foremost among these tools is the ability to knock down gene function through the use of RNA interference (RNAi). The fact that RNAi can be scaled up for use in high-throughput techniques has motivated the creation of genome-wide RNAi reagents. We are now at the brink of being able to harness the power of RNAi for large-scale functional discovery in mammalian cells.

PMID:
16496020
DOI:
10.1038/nrm1860
[PubMed - indexed for MEDLINE]
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